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原文連結
論文資訊
- 類型：已發表論文
- 日期：1997
摘要
The influence of host immuno遺傳s on the outcome of vertically transmitted HIV infection in children was examined in a multicenter cross sectional study of long term survivors and rapid progressors. Sequence-based typing was performed for the DRB1, DQB1 and HLA-A loci. 36.7% of 30 children surviving more than 8 years had one or more of the HLA-DR13 alleles, versus none of 14 rapidly progressing children who died within 2 years of age, p = 0.009, Haldane RR = 17.1, The alleles variably associated with this beneficial response to HIV were: DRB11301, DRB11302, DRB11303 and DRB11310, suggesting that che DR13 effect acted as a dominant trait. An additional 6 children were typed only by the SSOP method resulting in 44.4% of 36 long term surviving children with a DR13 allele and none of 14 rapi
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