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原文連結
論文資訊
- 類型：已發表論文
- 日期：1998
摘要
Estimation of 演化ary distances from coding sequences must take into account 蛋白質-level selection to avoid relative underestimation of longer 演化ary distances. Current modeling of selection via site-to-site rate heterogeneity generally neglects another aspect of selection, namely position-specific amino acid frequencies. These frequencies determine the maximum dissimilarity expected for highly diverged but functionally and structurally conserved sequences, and hence are crucial for estimating long distances. We introduce a codon-level model of coding sequence 演化 in which position-specific amino acid frequencies are free parameters. In our implementation, these are estimated from an alignment using methods described previously. We use simulations to demonstrate the importance and feasibility of
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