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原文連結
論文資訊
- 類型：已發表論文
- 日期：1998
摘要
The bovine papilloma病毒 type I (BPV-1) exonic splicing suppressor (ESS) is juxtaposed immediately downstream of BPV-1 splicing enhancer 1 and negatively modulates selection of a suboptimal 3' splice site at nucleotide 3225. The present study demonstrates that this pyrimidine-rich ESS inhibits utilization of upstream 3' splice sites by blocking early steps in spliceosome assembly. Analysis of the 蛋白質s that bind to the ESS showed that the U-rich 5' region binds U2AF(65) and polypyrimidine tract binding 蛋白質, the C-rich central part binds 35-and 54-55-kDa serine/arginine-rich (SR) 蛋白質s, and the AG-rich 3' end binds alternative splicing factor/splicing factor 2. 突變al and functional studies indicated that the most critical region of the ESS maps to the central C-rich core (GGCUCCCCC). This core s
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