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原文連結
論文資訊
- 類型：已發表論文
- 日期：1998
摘要
We present and analyze a model for the interaction of human immunodeficiency 病毒 type 1 (HIV-1) with target cells that includes a time delay between initial infection and the formation of productively infected cells. Assuming that the variation among cells with respect to this 'intracellular' delay can be approximated by a gamma distribution, a high flexible distribution that can mimic a variety of 生物ly plausible delays, we provide analytical solutions for the expected decline in plasma 病毒 concentration after the initiation of antiretroviral therapy with one or more protease inhibitors. We then use the model to investigate whether the parameters that characterize viral dynamics can be identified from 生物 data. Using non-linear least- squares regression to fit the model to simulated data in w
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