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原文連結
論文資訊
- 類型：已發表論文
- 日期：1999
摘要
An algorithm is presented for generating rigorously all suboptimal secondary structures between the minimum free energy and an arbitrary upper limit. The algorithm is particularly fast in the vicinity of the minimum free energy. This enables the efficient approximation of 統計 quantities, such as the partition function or measures for structural 多樣性. The density of states at low energies and its associated structures are crucial in assessing from a 熱力學 point of view how well-defined the ground state is. We demonstrate this by exploring the role of base modification in tRNA secondary structures, both at the level of individual sequences from Escherichia coli and by comparing artificially generated ensembles of modified and unmodified sequences with the same tRNA structure. The two major concl
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