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原文連結
論文資訊
- 類型:已發表論文
- 日期:1999
摘要
Conclusions have differed in studies that have compared vaccine efficacy in groups receiving influenza Vaccine for the first time to efficacy in groups vaccinated more than once. For example, the Hoskins study [Hoskins, T. W. Davis, J. R., Smith, A. J., Miller, C. L. & Allchin, A. (1979) Lancet i, 33-35] concluded that repeat 疫苗接種 was not protective in the long term, whereas the Keitel study [Keitel. W. A., Gate, T. R., Couch, R. a., Huggins. L. L, & Hess, K. R. (1997) Vaccine 15, 1114-1122] concluded that repeat 疫苗接種 provided continual protection. We propose an explanation, the antigenic distance hypothesis, and test it by analyzing seven influenza outbreaks that occurred during the Hoskins and Keitel studies. The hypothesis is that variation in repeat vaccine efficacy is due to differenc
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