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原文連結
論文資訊
- 類型：已發表論文
- 日期：2000
摘要
Many studies have shown that patients infected with hepatitis C 病毒 (HCV) of genotype 2 have better response to interferon (IFN)-alpha treatment than genotype 1 patients; however, the mechanisms responsible for this difference are not understood. In this study, viral dynamics during high-dose IFN induction treatment were compared between the genotypes, Patients in each group received 10 MU of IFN-alpha 2b for 14 days, and HCV RNA levels were frequently determined. 非線性 fitting, both individually for each patient and using a mixed-effects approach, of the viral kinetic data to a 數學 model of the IFN effect on HCV infection was performed, The antiviral effectiveness of IFN in blocking 病毒 production, the free virion clearance rate, and the HCV- infected cell death rate were all significantly hig
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