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原文連結
論文資訊
- 類型：已發表論文
- 日期：2000
摘要
The transformation of normal cells into 癌症ous cells is an 演化ary process. 族群s of pre癌症ous cells reproduce, mutate, and compete for resources. Some of these 突變s eventually lead to 癌症. We calculate the probability of developing 癌症 under a set of simplifying assumptions and then elaborate these calculations, culminating in a simple simulation of the cell dynamics. The 智能體-based model allows us to examine the interactions of 突變s critical for the development of 癌症 that are either 演化arily neutral or selective. We an also examine the interaction of these 突變s with a "mutator phenotype" derived from 突變 that raise the 突變 rate for the entire cell. The simulation suggest that there must be at least two selectively neutral 突變s necessary for th development of 癌症 and that preventive treatments will be mos
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