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原文連結
論文資訊
- 類型：已發表論文
- 日期：2001
摘要
In earlier work, human immunodeficiency 病毒 type 1 (HIV-1) sequences were analysed to estimate the timing of the ancestral sequence of the main group of HIV-1, the 病毒 that is responsible for the acquired 免疫 deficiency syndrome pandemic, yielding a best estimate of 1931 (95% confidence interval of 1915-1941). That work will be briefly reviewed, outlining how 系統發育 tools were extended to incorporate improved 演化ary models, how the molecular clock model was adapted to incorporate variable periods of latency, and how the approach was validated by correctly estimating the timing of two historically documented dates. The advantages, limitations, and assumptions of the approach will be summarized, with particular consideration of the implications of branch length uncertainty and recombination. We ha
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