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原文連結
論文資訊
- 類型：已發表論文
- 日期：2001
摘要
The estimation of 突變 rates is ordinarily performed using results based on the Luria-Delbruck distribution. There are certain difficulties associated with the use of this distribution in practice, some of which we address in this paper (others in the companion paper, Oprea and Kepler, Theor. Popul. Biol., 2001). The distribution is difficult to compute exactly, especially for large values of the random variable. To overcome this problem, we derive an integral representation of the Luria-Delbruck distribution that can be computed easily for large culture sizes. In addition, we introduce the usual assumption of very small probability of having a large proportion of mutants only after the generating function has been computed. Thus, we obtain 資訊 on the moments for the more general case. We exa
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