本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。
原文連結
論文資訊
- 類型：已發表論文
- 日期：2001
摘要
The germinal center reaction (GCR) of vertebrate immunity provides a remarkable example of 演化ary succession, in which an advantageous phenotype arises as a spontaneous 突變 from the parental type and eventually displaces the parental type altogether, In the case of the 免疫 response to the hapten (4-hydroxy-3-nitrophenyl)acetyl (NP), as with several other designed immunogens, the process is dominated by a single key 突變. which greatly simplifies the modeling of and analysis of data. We developed a two-stage model of this process in which the primary stage represents the appearance and establishment of the mutant 族群 as a 隨機 process while the second stage represents the growth and dominance of the clone as a deterministic process, conditional on its time of establishment from stage one, We applie
※ 此為已發表論文，全文需透過期刊付費取得