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原文連結
論文資訊
- 類型：已發表論文
- 日期：2002
摘要
The human cytotoxic T-lymphocyte (CTL) response to human immunodeficiency 病毒 type 1 (HIV-1) has been intensely studied, and hundreds of CTL epitopes have been experimentally defined, published, and compiled in the HIV Molecular Immunology Database. Maps of CTL epitopes on HIV-1 蛋白質 sequences reveal that defined epitopes tend to cluster. Here we integrate the global sequence and immunology databases to systematically explore the relationship between HIV-1 amino acid sequences and CTL epitope distributions. CTL responses to five HIV-1 蛋白質s, Gag p17, Gag p24, reverse transcriptase (RT), Env, and Nef, have been particularly well characterized in the literature to date. Through comparing CTL epitope distributions in these five 蛋白質s to global 蛋白質 sequence alignments, we identified distinct chara
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