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原文連結
論文資訊
- 類型：已發表論文
- 日期：2002
摘要
We analyse 計算 modules of a frequency decoding signal transduction 網絡. The gonadotropin releasing hormone (GnRH) signal transduction 網絡 mediates the biosynthesis and release of the gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH). The pulsatile pattern of GnRH production by the hypothalamus has a critical influence on the release and synthesis of gonadotropins in the pituitary. In humans, slower pulses lead to the expression of the beta-subunit of the LH 蛋白質 and cause anovulation and amenorrhea. Higher frequency pulses lead to expression of the a subunit and a hypogonadal state. The frequency sensitivity is a consequence of the structure of the GnRH signal transduction 網絡. We analyse individual components of this 網絡, organized into three 網絡 architectures, and d
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