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原文連結
論文資訊
- 類型：已發表論文
- 日期：2002
摘要
We aimed to investigate the influence of class I and class II HLA specificities and of the concordance between maternal and infant HLA on vertical HIV-1 傳播. HLA typing of samples from mothers and infants enrolled in the Ariel study, a perinatal HIV-1 傳播 cohort including 203 mother-infant pairs, was performed by serological and molecular methods. HLA effects were evaluated alone and by multivariate modeling considering also other known predictors of perinatal HIV-1 傳播 (maternal viral load, antiretroviral therapy, duration of rupture of membranes, and histological chorioamnionitis). Modest associations were seen with specific HLA markers (increased risk with infant B67 and B58 and maternal DR1 decreased risk with maternal B12), but these were not 統計ly significant after adjusting for multiple
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