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原文連結
論文資訊
- 類型：已發表論文
- 日期：2003
摘要
It is an open question whether phenomena such as phenotypic robustness to 突變 evolve as 適應s or are simply an inherent property of 遺傳 systems. As a case study, we examine this question with regard to dominance in metabolic physiology. Traditionally the conclusion that has been derived from Metabolic Control Analysis has been that dominance is an inevitable property of multi-enzyme systems and hence does not require an 演化ary explanation. This view is based on a 數學 result commonly referred to as the flux summation theorem. However it is shown here that for 突變s involving finite changes (of any magnitude) in enzyme concentration, the flux summation theorem can only hold in a very restricted set of conditions. Using both analytical and simulation results we show that for finite changes, the summa
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