摘要 Many so called pathogenic 細菌 such as Neisseria me

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論文資訊

• 類型：已發表論文
• 日期：2003

摘要

Many so-called pathogenic 細菌 such as Neisseria meningitidis, Haemophilus influenzae, Staphylococcus aureus and Streptococcus pneumoniae are far more likely to colonize and maintain 族群s in healthy individuals asymptomatically than to cause 疾病. 疾病 is a dead-end for these 細菌: virulence shortens the window of time during which 傳播 to new hosts can occur and the sub族群s of 細菌 actually responsible for 疾病, like those in the blood or cerebral spinal fluid, are rarely transmitted to new hosts. Hence, the virulence factors underlying their occasional pathogenicity must evolve in response to selection for something other than making their hosts sick. What are those selective pressures? We address this general question of the 演化 of virulence in the context of phase shifting in N. meningitidis, a 突變al pr

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