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原文連結
論文資訊
- 類型：已發表論文
- 日期：2003
摘要
The highly polymorphic human leukocyte antigen (HLA) class I molecules help to determine the specificity and repertoire of the 免疫 response. The great 多樣性 of these antigen-binding molecules confers differential advantages in responding to pathogens, but presents a major obstacle to distinguishing HLA allele-specific effects. HLA class I supertypes provide a functional classification for the many different HLA alleles that overlap in their peptide-binding specificities. We analyzed the association of these discrete HLA supertypes with HIV 疾病 progression rates in a 族群 of HIV-infected men. We found that HLA supertypes alone and in combination conferred a strong differential advantage in responding to HIV infection, independent of the contribution of single HLA alleles that associate with progr
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