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原文連結
論文資訊
- 類型：已發表論文
- 日期：2003
摘要
The 遺傳 演化 of human immunodeficiency 病毒 type 1 (HIV-1) in the 大腦 is distinct from that in lymphoid tissues, indicating tissue-specific compartmentalization of the 病毒. Few primary HIV-1 envelope glyco蛋白質s (Envs) from uncultured 大腦 tissues have been 生物ly well characterized. In this study, we analyzed 37 full-length env genes from uncultured 大腦 biopsy and blood samples from four patients with AIDS. 系統發育 analysis of intrapatient sequence sets showed distinct clustering of 大腦 relative to blood env sequences. However, no 大腦-specific signature sequence was identified. Furthermore, there was no significant difference in the number or positions of N-linked glycosylation sites between 大腦 and blood env sequences. The patterns of coreceptor usage were heterogeneous, with no clear distinction between 大腦
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