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原文連結
論文資訊
- 類型：已發表論文
- 日期：2004
摘要
In this paper, we use both 數學 modeling and simulation to explore homeostasis of peripheral 免疫 system effector cells, particularly alveolar macrophages. Our interest is in the distributed control mechanisms that allow such a 族群 to maintain itself. We introduce a multi-purpose simulator designed to study individual cell responses to local molecular signals and their effects on 族群 dynamics. We use the simulator to develop a model of growth factor regulation of macrophage proliferation and survival. We examine the effects of this form of regulation in the context of two competing hypotheses regarding the source of new alveolar macrophages. In one model, local cells divide to replenish the 族群; in the other, only cells migrating from circulation divide. We find that either scenario is plausible,
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