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原文連結
論文資訊
- 類型：已發表論文
- 日期：2004
摘要
Recently, an HLA-B3501-restricted cytotoxic T-lymphocytes (CTL) epitope in the nucleo蛋白質 (NP418-426) of influenza A 病毒es was identified, which exhibited a high degree of variability. In the present study, the recognition of epitope variants by human cytotoxic T-lymphocytes (CTL) was investigated. Human CD8+ CTL clones were specific for NP418-426 epitope variants within one subtype of influenza 病毒 or cross-reactive with hetero-subtypic variants. Positions in the 9-mer were identified as determinants of CTL-specificity. The in vivo existence of T cells cross-reactive with homo- and hetero-subtypic variants of the epitope was confirmed with 病毒-specific polyclonal T cell 族群s obtained from HLA-B3501+ blood donors. Based on CTL recognition patterns and the history of infection as assessed by s
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