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原文連結
論文資訊
- 類型：已發表論文
- 日期：2004
摘要
The extreme polymorphism in the human leukocyte antigen (HLA) class I region of the human 基因組 is suggested to provide an advantage in pathogen defence mediated by CD8(+) T cells(1-3). HLA class I molecules present pathogen-derived peptides on the surface of infected cells for recognition by CD8(+) T cells. However, the relative contributions of HLA-A and -B alleles have not been evaluated. We performed a comprehensive analysis of the class I restricted CD8(+) T- cell responses against human immunodeficiency 病毒 (HIV-1), 免疫 control of which is dependent upon 病毒-specific CD8(+) T-cell activity(4,5). In 375 HIV-1-infected study subjects from southern Africa, a significantly greater number of CD8(+) T-cell responses are HLA-B- restricted, compared to HLA-A (2.5-fold; P = 0.0033). Here we show t
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