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原文連結
論文資訊
- 類型：已發表論文
- 日期：2004
摘要
We have described previously the generation of an escape variant of human immunodeficiency 病毒 type I (HIV-1), under the selection pressure of AD101, a small molecule inhibitor that binds the CCR5 coreceptor (A. Trkola, S. E. Kuhmann, J. M. Strizki, E. Maxwell, T. Ketas, T. Morgan, P. Pugach, S. X. L. Wojcik, J. Tagat, A. Palani, S. Shapiro, J. W. Clader, S. McCombie, G. R. Reyes, B. M. Baroudy, and J. P. Moore, Proc. Natl. Acad. Sci. USA 99:395-400, 1002). The escape mutant, CC101.19, continued to use CCR5 for entry, but it was at least 20,000- fold more resistant to AD101 than the parental 病毒, CC1/85. We have now cloned the env genes from the the parental and escape mutant isolates and made chimeric infectious molecular clones that fully recapitulate the phenotypes of the corresponding is
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