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原文連結
論文資訊
- 類型：已發表論文
- 日期：2005
摘要
Background B Aims: Although hepatitis C 病毒 kinetics and 免疫 determinants during primary infection have been described, the 病毒-host interplay is not fully understood. We used 數學 modeling to elucidate and quantify 病毒-host dynamics. Methods: Ten chimpanzees were infected intrahepatically with H77-RNA (n = 3) or intravenously with infected serum. Blood samples were taken 1-3 times per week for 6 months. A new model was fitted to the observed HCV RNA and alanine aminotransferase (ALT) kinetics. Results: After infection, viral levels increased in a biphasic manner with a transient decline in between. This can be explained by a partial block (mean, 91%) of virion production, possibly due to an endogenous type I interferon response. After reaching maximum levels, a long viral plateau (mean, 6A log
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