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原文連結
論文資訊
- 類型：已發表論文
- 日期：2005
摘要
Observations that rates of molecular 演化 vary widely within and among lineages have cast doubts on the existence of a single "molecular clock." Differences in the timing of 演化ary events estimated from 遺傳 and fossil evidence have raised further questions about the accuracy of molecular clocks. Here, we present a model of nucleotide substitution that combines theory on metabolic rate with the now-classic neutral theory of molecular 演化. The model quantitatively predicts rate heterogeneity and may reconcile differences in molecular- and fossil-estimated dates of 演化ary events. Model predictions are supported by extensive data from mitochondrial and nuclear 基因組s. By accounting for the effects of body size and temperature on metabolic rate, this model explains heterogeneity in rates of nucleotide
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