摘要 Several HLA class I alleles have been associated

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論文資訊

• 類型：已發表論文
• 日期：2005

摘要

Several HLA class I alleles have been associated with slow human immunodeficiency 病毒 (HIV) 疾病 progression, supporting the important role HLA class I-restricted cytotoxic T lymphocytes (CTL) play in controlling HIV infection. HLA-B63, the serological marker for the closely related HLA-B1516 and HLA-B1517 alleles, shares the epitope binding motif of HLA-B57 and HLA-B58, two alleles that have been associated with slow HIV 疾病 progression. We investigated whether HIV-infected individuals who express HLA-B63 generate CTL responses that are comparable in breadth and specificity to those of HLA-B57/58-positive subjects and whether HLA-B63-positive individuals would also present with lower viral set points than the general 族群. The data show that HLA-B63-positive individuals indeed mounted respons

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