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原文連結
論文資訊
- 類型：已發表論文
- 日期：2007
摘要
Background: Recent experimental and 計算 studies have provided overwhelming evidence for a plethora of diverse transcripts that are unrelated to 蛋白質-coding genes. One subclass consists of those RNAs that require distinctive secondary structure motifs to exert their 生物 function and hence exhibit distinctive patterns of sequence conservation characteristic for positive selection on RNA secondary structure. The deep-sequencing of 12 drosophilid 物種 coordinated by the NHGRI provides an ideal data set of comparative 計算 approaches to determine those genomic loci that code for 演化arily conserved RNA motifs. This class of loci includes the majority of the known small ncRNAs as well as structured RNA motifs in mRNAs. We report here on a 基因組-wide survey using RNAz. Results: We obtain 16 000 high quality
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