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原文連結
論文資訊
- 類型：已發表論文
- 日期：2007
摘要
Centralized HIV-1 genes (consensus, most recent common ancestor and center of the tree) have recently been explored for induction of broadly reactive 免疫 responses to overcome the extraordinary 遺傳 多樣性 among HIV-1 strains. Although all of these strategies are based on artificial sequences predicted by computer programs, they retain 生物 function, and use the CCR5 co-receptor for entry into target cells as transmitted HIV-1 Envs. Results from laboratory animals indicate that centralized immunogens are superior to many wild-type immunogens for inducing cross-subtype T and B cell 免疫 responses. Structural modifications have improved the ability of consensus Envs to elicit antibody responses that neutralize a spectrum of HIV-1 Env pseudo病毒es. However, the more difficult to neutralize tier 2 Env pse
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