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原文連結
論文資訊
- 類型：已發表論文
- 日期：2008
摘要
Background: Neutral 網絡s or sets consist of all genotypes with a given phenotype. The size and structure of these sets has a strong influence on a 生物 system's robustness to 突變s, and on its evolvability, the ability to produce phenotypic variation; in the few studied cases of molecular phenotypes, the larger this set, the greater both robustness and evolvability of phenotypes. Unfortunately, any one neutral set contains generally only a tiny fraction of genotype space. Thus, current methods cannot measure neutral set sizes accurately, except in the smallest genotype spaces. Results: Here we introduce a generalized 蒙地卡羅 approach that can measure neutral set sizes in larger spaces. We apply our method to the genotype-to-phenotype mapping of RNA molecules, and show that it can reliably measure
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