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原文連結
論文資訊
- 類型：已發表論文
- 日期：2008
摘要
During the course of development cells undergo division producing a variety of cell types. Proliferation and differentiation are dependent on both 遺傳 programs, encoded by the cellular 基因組, and environmental cues produced by the local cellular environment imposing local selection pressures on cells. We explore the role that cellular signals play over a large range of potential parameter regimes, in minimizing developmental error: errors in differentiation where an inappropriate proportion of differentiated daughter cells are generated. We find that 營養級 factors produced by the 族群 of dividing cells can compensate for increased error rates when signals act through a form of positive feedback-survival signals. We operationalize these signals as the somatic niche and refer to their production as
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