摘要 Genomic instability is considered by many authors

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論文資訊

• 類型：已發表論文
• 日期：2008

摘要

Genomic instability is considered by many authors the key engine of tumorigenesis. However, mounting evidence indicates that a small 族群 of drug resistant 癌症 cells can also be a key component of tumor progression. Such 癌症 stem cells would define a compartment effectively acting as the source of most tumor cells. Here we study the interplay between these two conflicting components of 癌症 dynamics using two types of tissue architecture. Both 平均場 and multicompartment models are studied. It is shown that tissue architecture affects the pattern of 癌症 dynamics and that unstable 癌症s spontaneously organize into a heterogeneous 族群 of highly unstable cells. This dominant 族群 is in fact separated from the low-突變 compartment by an instability gap, where almost no 癌症 cells are observed. The possible impli

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