本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。
原文連結
論文資訊
- 類型：已發表論文
- 日期：2008
摘要
Human immunodeficiency 病毒 type 1 (HIV-1) 突變s that confer escape from cytotoxic T-lymphocyte (CTL) recognition can sometimes result in lower viral fitness. These 突變s can then revert upon 傳播 to a new host in the absence of CTL-mediated 免疫 selection pressure restricted by the HLA alleles of the prior host. To identify these potentially critical recognition points on the 病毒, we assessed HLA-driven viral 演化 using three 系統發育 correction methods across full HIV-1 subtype C proteomes from a cohort of 261 South Africans and identified amino acids conferring either susceptibility or resistance to CTLs. A total of 558 CTL-susceptible and -resistant HLA-amino acid associations were identified and organized into 310 immunological sets (groups of individual associations related to a single HLA/epitope co
※ 此為已發表論文，全文需透過期刊付費取得