摘要 Imprinted genes have been associated with a wide

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論文資訊

• 類型：已發表論文
• 日期：2008

摘要

Imprinted genes have been associated with a wide range of 疾病s. Many of these 疾病s have symptoms that can be understood in the context of the 演化ary forces that favored imprinted expression at these loci. Modulation of perinatal growth and resource acquisition has played a central role in the 演化 of imprinting and many of the 疾病s associated with imprinted genes involve some sort of growth or feeding disorder. In the first part of this chapter, we discuss the relationship between the 演化 of imprinting and the clinical manifestations of imprinting-associated 疾病s. In the second half, we consider the variety of processes that can disrupt imprinted gene expression and function. We ask specifically if there is reason to believe that imprinted genes are particularly susceptible to deregulation-and whe

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