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原文連結
論文資訊
- 類型：已發表論文
- 日期：2008
摘要
Many of the greatest challenges in medicine and public health involve the 演化 of drug resistance by pathogens. Recent advances in the theory of 自然選擇 suggest that there are two broad classes of pathogen traits that can be targeted by drugs or vaccines. The first class, consisting of traits that benefit the individual organisms bearing them, causes a strong 演化ary response and the rapid 湧現 of drug resistance. The second class, consisting of traits that benefit groups of pathogen organisms including the individual provider, causes a weaker 演化ary response and less drug resistance. Although most previous drug development has targeted the first class, it would be advantageous to focus on the second class as targets for drug and vaccine development. Specific examples and test cases are discussed.
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