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原文連結
論文資訊
- 類型：已發表論文
- 日期：2008
摘要
Motivation: In the last years more than 20 vertebrate 基因組s have been sequenced, and the rate at which genomic DNA 資訊 becomes available is rapidly accelerating. Gene duplication and gene loss events inherently limit the accuracy of orthology detection based on sequence similarity alone. Fully automated methods for orthology annotation do exist but often fail to identify individual members in cases of large gene families, or to distinguish missing data from traceable gene losses. This situation can be improved in many cases by including conserved synteny 資訊. Results: Here we present the SynBlast pipeline that is designed to construct and evaluate local synteny 資訊. SynBlast uses the genomic region around a focal reference gene to retrieve candidates for homologous regions from a collection of
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