摘要 One of the major challenges that must be met in d

本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。

原文連結

• SFI 頁面

論文資訊

• 類型：已發表論文
• 日期：2008

摘要

One of the major challenges that must be met in developing an HIV-1 vaccine is devising a strategy to generate cellular immunity with sufficient breadth to deal with the extraordinary 遺傳 多樣性 of the 病毒. Amino acids in the envelopes of 病毒es from the same clade can differ by >15%, and those from different clades can differ by >30%. It has been proposed that creating immunogens using centralized HIV-1 gene sequences might provide a practical solution to this problem. Such centralized genes can be generated by employing a number of different strategies: consensus, ancestral, or center of tree sequences. These computer-generated sequences are a shorter 遺傳 distance from any two contemporary 病毒 sequences than those contemporary sequences are from each other. The present study was initiated to eval

※ 此為已發表論文，全文需透過期刊付費取得