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原文連結
論文資訊
- 類型：已發表論文
- 日期：2008
摘要
The formation of antibodies to interferon-beta (IFN-beta), a 蛋白質-based 疾病-modifying 智能體 for multiple sclerosis (MS), is a problem in clinical practice. These antibodies may neutralize the 生物 effects of the 蛋白質 drug, potentially decreasing its therapeutic effects. By high-resolution HLA class I and II typing we identified two HLA class II alleles associated with the development of antibodies to IFN-beta. In two independent continuous and binary-trait association studies, HLA-DRB10401 and HLA-DRB10408 (odds ratio: 5.15)-but not other HLA alleles-were strongly associated with the development of binding and neutralizing antibodies to IFN-beta. The associated HLA-DRB104 alleles differ from nonassociated HLA-DRB104 alleles by a glycine-to-valine substitution in position 86 of the epitope-bin
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