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原文連結
論文資訊
- 類型：已發表論文
- 日期：2008
摘要
The precise identification of the HIV-1 envelope glyco蛋白質 (Env) responsible for productive clinical infection could be instrumental in elucidating the molecular basis of HIV-1 傳播 and in designing effective vaccines. Here, we developed a 數學 model of random viral 演化 and, together with 系統發育 tree construction, used it to analyze 3,449 complete env sequences derived by single 基因組 amplification from 102 subjects with acute HIV-1 (clade B) infection. Viral env genes evolving from individual transmitted or founder 病毒es generally exhibited a Poisson distribution of 突變s and star-like phylogeny, which coalesced to an inferred consensus sequence at or near the estimated time of 病毒 傳播. Overall, 78 of 102 subjects had evidence of productive clinical infection by a single 病毒, and 24 others had evidence o
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