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原文連結
論文資訊
- 類型：已發表論文
- 日期：2008
摘要
We present a suite of on-line tools to design candidate vaccine 蛋白質s, and to assess antigen potential, using coverage of k-mers (as proxies for potential T-cell epitopes) as a metric. The vaccine design tool uses the recently published mosaic method to generate 蛋白質sequences optimized for coverage of high-frequency k-mers; the coverage-assessment tools facilitate coverage comparisons for any potential antigens. To demonstrate these tools, we designed mosaic 蛋白質 sets for B-clade HIV-1 Gag, Pol and Nef, and compared them to antigens used in a recent human vaccine trial.
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