摘要 7SK RNA is a key player in the regulation of poly

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論文資訊

• 類型：已發表論文
• 日期：2009

摘要

7SK RNA is a key player in the regulation of polymerase II transcription. 7SK RNA was considered as a highly conserved vertebrate innovation. The discovery of poorly conserved homologs in several insects and lophotrochozoans, however, implies a much earlier 演化ary origin. The mechanism of 7SK function requires interaction with the 蛋白質s HEXIM and La-related 蛋白質 7. Here, we present a comprehensive 計算 analysis of these two 蛋白質s in metazoa, and we extend the collection of 7SK RNAs by several additional candidates. In particular, we describe 7SK homologs in Caenorhabditis 物種. Furthermore, we derive an improved secondary structure model of 7SK RNA, which shows that the structure is quite well-conserved across animal phyla despite the extreme divergence at sequence level.

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