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原文連結
論文資訊
- 類型：已發表論文
- 日期：2009
摘要
A detailed annotation of non-蛋白質 coding RNAs is typically missing in initial releases of newly sequenced 基因組s. Here we report on a comprehensive ncRNA annotation of the 基因組 of Trichoplax adhaerens, the presumably most basal metazoan whose 基因組 has been published to-date. Since blast identified only a small fraction of the best-conserved ncRNAsin particular rRNAs, tRNAs and some snRNAswe developed a semi-global dynamic programming tool, GotohScan, to increase the sensitivity of the homology search. It successfully identified the full complement of major and minor spliceosomal snRNAs, the genes for RNase P and MRP RNAs, the SRP RNA, as well as several small nucleolar RNAs. We did not find any microRNA candidates homologous to known eumetazoan sequences. Interestingly, most ncRNAs, including t
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