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原文連結
論文資訊
- 類型：已發表論文
- 日期：2009
摘要
An effective AIDS vaccine must control highly diverse circulating strains of human immunodeficiency 病毒 type 1 (HIV-1). Among HIV-1 gene products, the envelope (Env) 蛋白質 contains variable as well as conserved regions. In this report, an informatic approach to the design of T-cell vaccines directed to HIV-1 Env M group global sequences was tested. Synthetic Env antigens were designed to express mosaics that maximize the inclusion of common potential T-cell epitope (PTE) 9-mers and minimize the inclusion of rare epitopes likely to elicit strain-specific responses. DNA vaccines were evaluated using intracellular cytokine staining in inbred mice with a standardized panel of highly conserved 15-mer PTE peptides. One-, two-, and three-mosaic sets that increased theoretical epitope coverage were d
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