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原文連結
論文資訊
- 類型：已發表論文
- 日期：2009
摘要
Background: Metabolic 網絡s show great 演化ary plasticity, because they can differ substantially even among closely related prokaryotes. Any one metabolic 網絡 can also effectively compensate for the blockage of individual reactions by rerouting metabolic flux through other pathways. These observations, together with the continual discovery of new microbial metabolic pathways and enzymes, raise the possibility that metabolic 網絡s are only weakly constrained in changing their complement of enzymatic reactions. Results: To ask whether this is the case, I characterized pairwise and higher-order associations in the co-occurrence of genes encoding metabolic enzymes in more than 200 completely sequenced representatives of prokaryotic genera. The majority of reactions show constrained 演化. Specifically,
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