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原文連結
論文資訊
- 類型：已發表論文
- 日期：2009
摘要
HIV-1 can evolve HLA-specific escape variants in response to HLA-mediated cellular immunity. HLA alleles that are common in the host 族群 may increase the frequency of such escape variants at the 族群 level. When loss of viral fitness is caused by 免疫 escape variation, these variants may revert upon infection of a new host who does not have the corresponding HLA allele. Furthermore, additional escape variants may appear in response to the nonconcordant HLA alleles. Because individuals with rare HLA alleles are less likely to be infected by a partner with concordant HLA alleles, viral 族群s infecting hosts with rare HLA alleles may undergo a greater amount of 演化 than those infecting hosts with common alleles due to the loss of preexisting escape variants followed by new 免疫 escape. This hypothesis
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