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原文連結
論文資訊
- 類型：已發表論文
- 日期：2009
摘要
Identification of full-length transmitted HIV-1 基因組s could be instrumental in HIV-1 pathogenesis, microbicide, and vaccine research by enabling the direct analysis of those 病毒es actually responsible for productive clinical infection. We show in 12 acutely infected subjects (9 clade B and 3 clade C) that complete HIV-1 基因組s of transmitted/founder 病毒es can be inferred by single 基因組 amplification and sequencing of plasma virion RNA. This allowed for the molecular cloning and 生物 analysis of transmitted/founder 病毒es and a comprehensive 基因組-wide assessment of the 遺傳 imprint left on the evolving 病毒 quasi物種 by a composite of host selection pressures. Transmitted 病毒es encoded intact canonical genes (gag-pol-vif-vpr-tat-rev-vpu-env-nef) and replicated efficiently in primary human CD4(+) T lymphocyte
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