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原文連結
論文資訊
- 類型：已發表論文
- 日期：2009
摘要
Identifying the specific 遺傳 characteristics of successfully transmitted variants may prove central to the development of effective vaccine and microbicide interventions. Although human immunodeficiency 病毒 傳播 is associated with a 族群 bottleneck, the extent to which different factors influence the 多樣性 of transmitted 病毒es is unclear. We estimate here the number of transmitted variants in 69 heterosexual men and women with primary subtype C infections. From 1,505 env sequences obtained using a single 基因組 amplification approach we show that 78% of infections involved single variant 傳播 and 22% involved multiple variant 傳播s (median of 3). We found evidence for 突變s selected for cytotoxic-T-lymphocyte or antibody escape and a high prevalence of recombination in individuals infected with multiple var
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