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原文連結
論文資訊
- 類型：已發表論文
- 日期：2009
摘要
The availability of interaction data between small molecule drugs and 蛋白質 targets has increased substantially in recent years. Using seven different databases, we were able to assemble a total of 4767 unique interactions between 802 drugs and 480 targets, which means that on average every drug is currently acknowledged to interact with 6 targets. The application of 網絡 theory to the analysis of these data reveals an unexpectedly complex picture of drug-target interactions. The results confirm that the topology of drug-target 網絡s depends implicitly on data completeness, drug properties, and target families. The implications for drug discovery are discussed.
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