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原文連結
論文資訊
- 類型：已發表論文
- 日期：2009
摘要
The pattern of viral diversification in newly infected individuals provides 資訊 about the host environment and 免疫 responses typically experienced by the newly transmitted 病毒. For example, sites that tend to evolve rapidly across multiple early-infection patients could be involved in enabling escape from common early 免疫 responses, could represent 適應 for rapid growth in a newly infected host, or could represent reversion from less fit forms of the 病毒 that were selected for 免疫 escape in previous hosts. Here we investigated the diversification of HIV-1 env coding sequences in 81 very early B subtype infections previously shown to have resulted from 傳播 or expansion of single 病毒es (n = 78) or two closely related 病毒es (n = 3). In these cases, the sequence of the infecting 病毒 can be estimated accur
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