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原文連結
論文資訊
- 類型:已發表論文
- 日期:2009
摘要
The topology of metabolic 網絡s can provide insight not only into the metabolic processes that occur within each 物種, but also into interactions between different 物種. Here, we introduce a novel pair-wise, topology-based measure of biosynthetic support, reflecting the extent to which the nutritional requirements of one 物種 could be satisfied by the biosynthetic capacity of another. To evaluate the biosynthetic support for a given pair of 物種, we use a graph-based algorithm to identify the set of exogenously acquired compounds in the metabolic 網絡 of the first 物種, and calculate the fraction of this set that occurs in the metabolic 網絡 of the second 物種. Reconstructing the metabolic 網絡 of 569 細菌l 物種 and several eukaryotes, and calculating the biosynthetic support score for all 細菌l-eukaryotic pairs, w
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