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原文連結
論文資訊
- 類型：已發表論文
- 日期：2009
摘要
User-driven in silico RNA homology search is still a nontrivial task. In part, this is the consequence of a limited precision of the 計算 tools in spite of recent exciting progress in this area, and to a certain extent, 計算 costs are still problematic in practice. An important, and as we argue here, dominating issue is the dependence on good curated (secondary) structural alignments of the RNAs. These are often hard to obtain, not so much because of an inherent limitation in the available data, but because they require substantial manual curation, an effort that is rarely acknowledged. Here, we qualitatively describe a realistic scenario for what a "regular user'' (i.e., a nonexpert in a particular RNA family) can do in practice, and what kind of results are likely to be achieved. Despite the
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