摘要 We recently developed a novel strategy to identif

本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。

原文連結

• SFI 頁面

論文資訊

• 類型：已發表論文
• 日期：2009

摘要

We recently developed a novel strategy to identify transmitted HIV-1 基因組s in acutely infected humans using single-基因組 amplification and a model of random 病毒 演化. Here, we used this approach to determine the molecular features of simian immunodeficiency 病毒 (SIV) 傳播 in 18 experimentally infected Indian rhesus macaques. Animals were inoculated intrarectally (i.r.) or intravenously (i.v.) with stocks of SIVmac251 or SIVsmE660 that exhibited sequence 多樣性 typical of early-chronic HIV-1 infection. 987 full-length SIV env sequences ( median of 48 per animal) were determined from plasma virion RNA 1-5 wk after infection. i.r. inoculation was followed by productive infection by one or a few 病毒es (median 1; range 1-5) that diversified randomly with near starlike phylogeny and a Poisson distribution of

※ 此為已發表論文，全文需透過期刊付費取得